The antibacterial activity of Hibiscus rosa-sinensis extract on methicillin-resistant Staphylococcus aureus and multi-drug resistance Acinetobacter baumanii Isolates.

Document Type : Original Article

Authors

1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

2 Microbiology specialist in microbiology department in National Bank of Egypt Hospital

Abstract

Background: Increasing untreatable infections caused by multi-drug resistant (MDR) bacteria necessitate development of new antibacterial agents. Natural plant extracts considered an appropriate alternative to antibiotics. Studies have shown that Hibiscus rosa-sinensis (H.rosa-sinensis) extract has a wide antibacterial, antipyretic, anti inflammatory and antioxidant effects. Aim: To detect the antibacterial activity and potential synergistic effect of H.rosa-sinensis extract on Methicillin-Resistant Staphylococcus aureus (MRSA) and MDR Acinetobacter baumannii (A. baumanii)isolates. Methods: The present study was done on 30 MRSA and 30 MDR A. baumanii isolates. For each bacterial isolate antimicrobial susceptibility was done before and after addition of H.rosa-sinensis extract to the tested antibiotics. The synergestic effect of H. rosa-sinensis extract addition was detected by the percent of change in the zone of inhibition for the combined H.rosa-sinensis extract/antibiotic disc in comparison to the antibiotic disc alone. Results: There was statistically significant increase in zone of inhibition of all used antibiotics against tested bacterial isolates after H.rosa-sinensis extract addition.For MRSA the synergestic effect of H.rosa-sinensis extract was detected in 53.3% of tested MRSA isolates for oxacillin and 3.3 % for vancomycin. For MDR A.baumanii, the synergestic effect of H.rosa-sinensis was detected in 86.7%of tested MDR A. baumanii isolates in cefoxitin and 80% in cefotaxime, cefazidime, cefepime and ciprofloxacin. Conclusion: H.rosa-sinensis is a natural extract that showed marked antibacterial and synergistic effect on MRSA and MDR A.baumanii isolates. H.rosa-sinensis extract/antibiotic combination is a potential alternative to the conventional antibiotics with less side effect.

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