Antibodies to HIV-1 specific antigens in HBV and HCV coinfected patients in Warri, Nigeria

Document Type : Original Article

Authors

1 Medical Laboratory Department, Edo State University, Uzairue, Edo State, Nigeria

2 Public Health Department, Torrens University, Adelaide, Australia

3 Medical Laboratory Department, Nigerian Navy Hospital, Warri, Delta State, Nigeria

Abstract

Background: Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) are critical global public health issues, particularly in resource-limited settings like Warri, Nigeria, where healthcare systems face significant challenges. This study investigates the prevalence of antibodies to HIV-1-specific antigens in HBV and HCV-coinfected patients in Warri. Materials and Methods: Utilizing a cross-sectional design, 350 HIV-positive individuals were systematically sampled, and their blood samples were analyzed using ELISA and Western blot techniques. Results: Among the participants, 17.7% were coinfected with HBV and 10.9% with HCV. A high prevalence of antibodies to HIV-1 gp120, gp41, and p24 was observed, with no significant differences between the HBV and HCV coinfected groups (p > 0.05). Conclusion: These findings highlight the impact of HBV and HCV coinfections on the humoral immune response to HIV-1. Our study underscores the need for integrated diagnostic and therapeutic strategies to improve patient care in resource-limited settings. Understanding these interactions is crucial for developing effective management approaches for patients with HIV, HBV, and HCV coinfections.

Keywords

Main Subjects

Microbes and Infectious Diseases

Articles in Press, Accepted Manuscript
Available Online from 17 July 2024

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