Relationships between some antibiotics resistance of human intestinal E. coli and antibiotic consumption

Alhusayni, Ali Abedulameer; AL-Khikani, Falah Hasan Obayes; AL-Kharawy, Bassim Abed Ali

doi:10.21608/mid.2024.261531.1751

Relationships between some antibiotics resistance of human intestinal E. coli and antibiotic consumption

Document Type : Original Article

Authors

¹ Department of Microbiology, Al-Shomali General Hospital, Babylon Health Directorate, Babylon, Iraq.

² Department of Microbiology, Al-Shomali General Hospital, Babylon Health Directorate, Babylon, Iraq

³ Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq

10.21608/mid.2024.261531.1751

Abstract

Background: Antibiotics wrong uses are a primary driver of antibiotic resistance, and reducing these useless antibiotics consumption is a central strategy for combatting resistance. Understanding the relationship between antibiotic consumption and antibiotic resistance is therefore critical for the design of rational antibiotic stewardship strategies. The purpose of the current study was to detect a relationship between some antibiotic’s consumption and antibiotic resistance in intestinal E. coli. Materials and Methods: A total of 100 stool samples were isolated from patients divided to consumers and non- consumer’s antibiotics. Patients who are taking Ceftriaxone (CRO) were divided to 50 consumers and 50 non- consumers. Patients who are taking Ciprofloxacin (CIP) were divided to 55 consumption and 45 non-consumptions. Patients who are consuming Augmentin (AUG) were divided to 29 consumers and 71 non- consumers antibiotic. Consumers all were non- hospitalized patients and were consuming antibiotics randomly without physician recipe. Results: Antibiotic susceptibility testing revealed Ceftriaxone was 47 (95.9%) inactive in consumers patients against E. coli while CRO was 2(4.1%) inactive in non- consumers patients. E. coli was resistant in 40 (81.6%) in consumers patients to CIP whereas it revealed 9 (18.4%) resistance to CIP in non- consumers patients. For AUG, E. coli was resistant in 25 (89.3%) of consumers patients whereas it revealed 3 (10.7%) resistance in non- consumers patients. Conclusion: This study revealed high relationships between consumption of antibiotics and E. coli resistance. People who are non-consumption antibiotic have high sensitivity to E. coli. Antibiotics usage apparently affects microbiota sensitivity.

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