Prevalence of rifampicin resistance among tuberculous Patients In Khartoum State, Sudan

Ismail Hamed, Mohammed Alhadi; Hammad, Mohammed Aldai; Idris, Alkhair Abd Almahmoud

doi:10.21608/mid.2024.248984.1663

Prevalence of rifampicin resistance among tuberculous Patients In Khartoum State, Sudan

Document Type : Original Article

Authors

¹ Department of Graduate College and Scientific Studies, Gharb El-Niel College-Sudan

² Department of Medical Laboratory Sciences- Dar ALaloum College-Sudan

³ Ahfad University for Women, Sudan

10.21608/mid.2024.248984.1663

Abstract

Background: Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Rifampicin resistant tuberculosis (RR-TB) defined as resistance to rifampicin detected using genotypic or other first method with or without resistance to other first line anti-TB drugs, RR-TB is emerging as a major problem due to poor management of drug sensitive as well as drug resistance TB. Objectives: The study aimed to determine the prevalence of the drug resistant (rifampicin among TB patients) in Khartoum state. Material and methods: This study was cross-sectional study performed on 75 Sudanese individuals; sputum samples were collected from 75 patients with tuberculosis; whose are sub divided according to their severity into mild patients and high patients. The drug resistance (rifampicin) among T.B patients detected by GeneXpert. The statistical analysis was conducted using SPSS 26 computer program. Results: This study was conducted among 75 Sudanese patients with tuberculosis as case group. Mean and SD of age was (30.6 ± 6.4 years). Age was grouped to four age group; the most common age group was between 21-30 years. It was found that two patients had resistant strains of M. tuberculosis. Conclusion: The study concluded that Gene-Xpert MTB/RIF is a useful tool for detection of TB and RIF resistance on primary respiratory specimens.

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