Oral bacteria-related systemic diseases: A therapeutic prospect

Document Type : Letter to the Editor


Division of Dermatology, Tsuruse Orthopedic Clinic, Saitama, Japan


Recently, evidence has suggested that periodontal disease, such as periodontitis, may be associated with other systemic diseases such as cardiovascular diseases, type 2 diabetes and Alzheimer’s disease. The pathogenesis of these systemic diseases caused by oral bacteria is very different from that of leukocyte-mediated inflammation in palmoplantar pustulosis, known for its peculiar clinical picture of prominent pustules accompanying erythematous plaques affecting the palms and soles, but in Alzheimer’s disease, there is accumulation of bacterial components and immune reactants in the brain. No improvement was observed in the symptoms of both Alzheimer’s disease and type 2 diabetes even after oral cleaning with ozonated water, dissolved nanosized ozone gas bubbles in water, for several months. These diseases will require ozone water treatment at early stages of the disease course. Even if these systemic diseases are caused by oral bacteria, it is assumed that the pathogenic mechanism differs, depending on the individual disease.


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