Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles

Document Type : Original Article

Authors

1 Sourô Sanou University Hospital, Laboratory of Bacteriology-Virology, 01 BP 676, Bobo-Dioulasso, Burkina Faso

2 Regional University Hospital of Ouahigouya, Laboratory of Biomedical Analysis, 01 BP 36, Ouahigouya, Burkina Faso

3 10- University of Montpellier, 163 rue Auguste Broussonnet 34090 Montpellier, France

4 NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

5 Sourô Sanou University Hospital, Department of Pediatrics, 01 BP 676, Bobo-Dioulasso, Burkina Faso

6 Adam Barak University of Abéché, 02 BP 1173, Abéché, Tchad

7 Department of Urology-Andrology, Tenkodogo Regional Hospital Center, 01 BP 56, Tenkodogo, Burkina Faso

8 Sourô Sanou University Hospital, Department of Nephrology-Hemodialysis, 01 BP 676, Bobo-Dioulasso, Burkina Faso

9 Sourô Sanou University Hospital, Department of Information, Epidemiology, Research and Planning, 01 BP 676, Bobo-Dioulasso, Burkina Faso

10 Sourô Sanou University Hospital, Department of Infectious Diseases, 01 BP 676, Bobo-Dioulasso, Burkina Faso

11 Arnaud de Villeneuse University Hospital, Bacteriology Laboratory, 34 295 Montpellier Cedex 5, France

12 University of Montpellier, 163 rue Auguste Broussonnet 34090 Montpellier, France

Abstract

Background: The emergence of antimicrobial resistance (AMR) within bacterial pathogens necessitates a local comprehension of the epidemiological context. This information is indispensable for both clinical therapeutic determinations and the reevaluation of prevailing care protocols. This study aimed to highlight the antibiotic susceptibility profile of uropathogenic bacteria isolated within a university hospital in Burkina Faso, with a focus on enhancing probabilistic antibiotic therapy for both community and hospital-based urinary tract infections (UTIs). Methodology: Data from cytological urine analysis and antimicrobial susceptibility testing spanning 29 months (January 2017 to May 2019) was retrospectively collected and systematically analyzed. Results: In both hospital and community based UTIs, Enterobacterales dominated, constituting 79.86% (81.27% vs. 79.11%) of isolates. This was followed by non-fermentative Gram-negative bacteria at 6.60% (6.35% vs. 6.88%) and Gram-positive cocci at 6.41% (7.98% vs. 5.57%). Escherichia coli (61.37%), Klebsiella pneumoniae (10.66%), and Enterobacter spp. emerged as the predominant pathogens in the same rank regardless of the origin of the ITUs. Imipenem (97.19%), amikacin (69.26%), ceftriaxone (58.44%), and ciprofloxacin (47.60%) displayed superior susceptibility against all uropathogens. Subtle but significant variations emerged between hospital and community strains' susceptibility to various antibiotics, including amoxicillin + clavulanic acid (26.05% vs. 32.26%), Imipenem (96.43% vs. 98.59%), and ciprofloxacin (45.51% vs. 51.41%). Conclusion: Penicillins showcased diminished efficacy against uropathogens, while resistance to fluoroquinolones escalated. The combined use of aminoglycosides and third-generation cephalosporins holds promise as an optimal probabilistic therapy for UTIs. Notably, the profiles of hospital and community UTIs showed substantial similarities in terms of implicated uropathogens, yet hospital strains demonstrated higher resistance levels.

Keywords

Main Subjects

Files

Share

How to cite

Statistics