Fecal carriage rates Of extended-spectrum Β-lactamase-producing Escherichia coli of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.

Document Type : Original Article

Authors

1 Department of Microbiology, Faculty of Science, University of Maiduguri, Nigeria.

2 Department of Microbiology, Faculty of Science, Federal University Birnin Kebbi, Kebbi State, Nigeria

3 Department of Medical Laboratory Science, Faculty of Health Sciences, Taraba State University Jalingo

4 Department of Biochemistry, Kampala International University Western Campus, Ishaka, Uganda

5 Department of Microbiology, Faculty of Science, Federal University Wukari, Taraba State

6 Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University Sokoto

7 Department of Microbiology, Faculty of Life Science, Ahmadu Bello University Zaria.

Abstract

Background: Extended-spectrum β-lactamases-producing Escherichia coli has been on rise and its infection is becoming difficult to treat. These resistant bacteria can colonize human gastrointestinal tract and can easily be spread in population. The aim of this study was to assess the fecal carriage rates of extended spectrum beta lactamase-producing E. coli (ESBL) among hospitalized and out-patients.  Methods: A total of 200 volunteers participated in the study. A stool sample was collected from each participant and subjected to standard microbiological methods for the isolation of E. coli. Furthermore, the isolates were subjected to phenotypic detection of ESBL using double-disk synergy test. The confirmatory test was performed with CAZ (30μg), CTX (30μg) and CRO (30μg) around Augmentin disc (AMC 30μg) and clear zone of inhibitions towards the AMC (30μg) considered as positive results for production of ESBL. Basic demographic information were recorded. Results: From the 200 fecal samples collected, all tested positive for E. coli. 108 females participated which represents (54%) while 92 males participated which represents (46%) and their age group ranges between 21years to 40years (n =94/200; 47%). Among the participants, 113/200 (56. 5%) were out-patients while 87/200 representing 43.5% were hospitalized patients. In this study, 116/200 (58%) of the 200 volunteers were found to harbored E. coli producing ESBL. In this study, age, gender, and hospitalization status play role in fecal carriage rates of ESBL-producing E. coli.  Conclusion: The results of this study reveal high fecal colonization of ESBL-producing E. coli. Therefore, there is need for prudent use of antibiotics among hospitalized and out-patientsز

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