Document Type : Mini-review article
Authors
1
Professor, Department of Prosthodontics and Crown and Bridge, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar 751003, Odisha, India.
2
Central Research Laboratory, Institute of Dental Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha
3
Professor, Department of Prosthodontics and Crown and Bridge, SCB Dental College and Hospital, Cuttack 753007, Odisha, India
4
Professor, Department of Prosthodontics and Crown and Bridge, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar 751003, Odisha, India
Abstract
Background: Clustered Regularly Inter Spaced Palindromic Repeats (CRISPR) is programmable protein that can change the genome's content, remove it, and switch it on and off. This cutting-edge technology offers a wide range of uses and has the potential to change the future of oral health. Because of its efficacy and precision, the CRISPR-associated protein 9 (Cas9) genome editing technology could be a promising therapeutic tool in the treatment of oral cancer. It quickly changes the genetic makeup of cell lines, organs, and animals. As a result, gene editing has expanded to include genome-wide screening for both loss and augmentation of function. The CRISPR-Cas9 genome editing method and its uses in dentistry have been summarised in this study.
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