Secondary multidrug resistant bacterial pneumonia among adult COVID-19 patients: A molecular study

Document Type : Original Article

Authors

1 Medical Microbiology and Immunology department, Faculty of Medicine, Ain Shams University.

2 Clinical Pathology Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.

3 Medical Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

4 Laboratory Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

5 Infection Control Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

6 Surgery Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

7 Radiology department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.

8 Jeddah Regional Laboratory, Jeddah, Saudi Arabia

Abstract

Background: Secondary bacterial pneumonia especially with multidrug resistant (MDR) organisms is one of the devastating complications that can worsen COVID-19 patients’ outcomes.The study aimed to evaluate the impact of secondary MDR bacterial pneumonia on COVID-19 patients’ outcomes with molecular detection of genes involved in antimicrobial resistance among isolates of the most prevalent causative pathogen. Methods: Thestudy included 50 critically ill patients with acute severe COVID-19 with evidence of secondary MDR bacterial pneumonia, 50 critically ill patients with acute severe COVID-19 without evidence of secondary bacterial pneumonia, and 30 clinically stable patients with acute moderate COVID-19 infections. Respiratory samples were cultured for identification and antibiotic susceptibility of the causative pathogens. MDR/XDR A. baumannii, the most prevalent pathogen, was screened for multiple antibiotic resistance genes using single-plex and multiplex polymerase chain reactions. Results: Critically ill COVID-19 patients with secondary MDR bacterial pneumonia in group I had a significantly higher mortality rate.MDR/XDR A. baumannii was the most prevalent pathogen (39.2%) isolated with the highest cause specific mortality rate (38%). Multiple resistance genes were detected including π‘π‘™π‘ŽOXA-51, π‘π‘™π‘ŽOXA-48, π‘π‘™π‘ŽOXA-24, π‘π‘™π‘ŽADC,π‘π‘™π‘ŽCIT, π‘π‘™π‘ŽKPC, aacA4, aacC1, acc (6’), aphA1, aph6, and aadA1. Conclusion: Secondary MDR bacterial pneumonia had a significant impact on critically ill COVID-19 patients with a significantly higher mortality rate. Thus, preventing secondary MDR bacterial pneumonia through infection prevention measures, including standard precautions, preventive care bundles and antimicrobial stewardship programs, should be strictly implemented to protect critically ill COVID-19 patients and help avoid its detrimental effect on patients’ outcomes.

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