Do CRP levels predict severity in COVID-19 hospitalized Egyptian patients?

Document Type : Original Article

Authors

1 Department of Internal Medicine/ Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University.

2 Department of Internal Medicine / Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University.

3 Department of Family Medicine, Faculty of Medicine, Ain Shams University

4 Department of Clinical Pathology, Faculty of Medicine, Ain Shams University.

5 Department of Radiology, Faculty of Medicine, Ain Shams University.

6 Department of Anesthesiology and Intensive care, Faculty of Medicine, Ain Shams University.

7 Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University.

Abstract

Background:  Coronavirus disease 2019 (COVID-19) is a rapidly spreading virus with a wide range of clinical manifestations. To manage treatment programs and promptly assess patient severity, prognostic factors must be identified early. Objectives: The purpose of this study was to investigate if there was a link between the severity of COVID-19 and the C-reactive protein (CRP) level on admission. Methods: On admission clinical and laboratory data from 323 patients with laboratory-confirmed COVID-19 were gathered from an Isolation Hospital records from April 10, 2020 to July 30, 2020. CRP was determined in all participants using an automated analyzer and a commercially available latex-enhanced immuno-turbidimetric assay. Results: The most prevalent presenting symptom was fever (39.3%), followed by cough (38.4%).  Coronavirus disease 2019 severity and ICU admission were both predicted by high CRP levels (p < /em><0.001).  C-reactive protein levels were also greater in those who had more chest discomfort, as indicated by CT chest abnormalities (p < /em><0.001). Conclusion: Serum CRP is a simple and effective prognosticator for early prediction of COVID-19 severity.

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