Shams Eldeen, M., Khalil, H., Abdelghafar, M., Ibrahim, H., Abdelwahab, M. (2022). Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients.. Microbes and Infectious Diseases, 3(2), 262-269. doi: 10.21608/mid.2022.115485.1233
Maii Atef Shams Eldeen; Haidy Khalil; Mohamed Abdelghafar; Hoda Ali Ibrahim; Marwa A. Abdelwahab. "Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients.". Microbes and Infectious Diseases, 3, 2, 2022, 262-269. doi: 10.21608/mid.2022.115485.1233
Shams Eldeen, M., Khalil, H., Abdelghafar, M., Ibrahim, H., Abdelwahab, M. (2022). 'Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients.', Microbes and Infectious Diseases, 3(2), pp. 262-269. doi: 10.21608/mid.2022.115485.1233
Shams Eldeen, M., Khalil, H., Abdelghafar, M., Ibrahim, H., Abdelwahab, M. Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients.. Microbes and Infectious Diseases, 2022; 3(2): 262-269. doi: 10.21608/mid.2022.115485.1233
Role of measuring serum procalcitonin and receiving prophylactic antibiotic therapy in critical COVID-19 patients.
1Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt.
2Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Helwan University, Egypt.
3Assistant professor of Anesthesia, Surgical Intensive Care and Pain, Faculty of Medicine, Tanta University. Egypt.
4Lecturer of Medical Biochemistry, Faculty of Medicine, Tanta University. Egypt.
Abstract
Background:Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared as a pandemic in 2019-2020. Most cases are usually self- limited; however, it may unpredictably progress to severe form with high mortality rate. Objectives: To highlight the role of measuring serum procalcitonin (PCT) and receiving early prophylactic antibiotic therapy in terms of their relation to the mortality rate in hospitalized critical COVID-19 patients. Methods: this study analyzed sixty COVID-19 critical patients admitted to Tanta University Isolation Hospital from June to November, 2020. Respiratory tract and blood samples were collected Results: Our results showed that the mean serum PCT levels were significantly higher in deceased patients (15%) than in those who could survive corona-virus infection. Patients who received early prophylactic antibiotic therapy showed significant better survival rate than those who didn’t. Conclusion: This study demonstrated that measuring PCT shows statically significant results with COVID-19 patients’ outcome more than other commonly used laboratory markers such as CRP. Moreover, early administration of prophylactic antibiotic therapy in COVID-19 patients, especially critical ones, is crucial even in those with negative PCT values.
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