Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine.

Document Type : Original Article


Chemistry Department Yobe State University Damaturu Nigeria


Aim and methods: The Schiff base was synthesized by condensation of 2-hydroxy-1-naphthaldehyde with 2-amino-3-methylpyridine and its complexes of Fe (II), Ni (II) and Co (II) chlorides were synthesized and characterized by melting point, solubility test, conductivity, measurement, magnetic susceptibility measurement and  infrared (IR) spectroscopy. The Schiff base and its respective metal complexes were colored with sharp melting point and are soluble in ethanol, dimethylsulfuroxide and methanol but insoluble in water and slightly soluble in other solvent. The conductivity value obtained indicates that the synthesized complexes are non-electrolytes while an octahedral geometry was suggested for all complexes based on the data obtained from magnetic susceptibility analysis. Results: The IR results revealed bands at 1596cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. 791cm-1, 683cm-1, 747cm-1 for (M-N) and 447cm-1, 461cm-1, 451cm-1 for (M-O) bands in the spectra of the complexes supporting coordination of Schiff base to respective metals. Conclusion: The in vitro antimicrobial screening of Schiff base and its metal complexes against  Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia, Klebsiella pneumonia, Aspergillus niger and Candida albicans   showed that they are potential antibacterial and antifungal agents against the tested microorganisms.


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