Mekky, J., Ahmad, S., Metwali, M., Farouk, S., Monir, S., ElSayed, A., Asser, S. (2022). Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species. Microbes and Infectious Diseases, 3(2), 420-427. doi: 10.21608/mid.2022.110401.1218
Jaidaa Mekky; Shwikar Ahmad; Mona Metwali; Samar Farouk; Shehab Monir; Ahmed ElSayed; Sara Asser. "Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species". Microbes and Infectious Diseases, 3, 2, 2022, 420-427. doi: 10.21608/mid.2022.110401.1218
Mekky, J., Ahmad, S., Metwali, M., Farouk, S., Monir, S., ElSayed, A., Asser, S. (2022). 'Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species', Microbes and Infectious Diseases, 3(2), pp. 420-427. doi: 10.21608/mid.2022.110401.1218
Mekky, J., Ahmad, S., Metwali, M., Farouk, S., Monir, S., ElSayed, A., Asser, S. Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species. Microbes and Infectious Diseases, 2022; 3(2): 420-427. doi: 10.21608/mid.2022.110401.1218
Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species
1Department of Neuropsychiatry, Faculty of Medicine, Alexandria University, Egypt
2Department of Medical Microbiology and Immunology, Faculty of Medicine, Alexandria University, Egypt
3Alexandria University Faculty of Medicine, Egypt
Abstract
Background: The gut microbiome is speculated to play a crucial role in its pathogenesis of Parkinson’s disease as a triggering factor. Recent hypotheses suggested that Prevotella species regulate gut permeability, exert a neuroprotective effect, and interestingly, has been suspected to be deficient in PD patients, and so may play a role in this disease. Aim: This study was designed to compare between PD patients and their healthy controls as regards relative Prevotella abundance, prevalence of Prevotella-dominant Enterotype, and constipation severity. Also, to correlate Prevotella changes with the clinical phenotypes and severity of motor and non-motor symptoms of PD. Methods: Twenty-five PD cases were enrolled in this study and cross-matched to 25 healthy subjects representing the control group. Overall NMS severity was assessed using the Non-Motor Symptoms Scale (NMSS). Quantitative SYBR green Real Time PCR was performed for the identification and quantitation of Prevotella in stool. Results:Prevotella relative abundance was 4-fold decreased in cases when compared to controls with PIGD phenotype showing the lowest abundance, however the difference was not statistically significance. Prevotella-dominant Enterotype was less presented in cases compared to controls, the result was statistically significant. Severe and very severe constipation grades presented 64% of cases group Vs 12% of control group. There was statistically significant positive correlation between total constipation score and UPDRS total score and motor symptoms phenotypes. Conclusion: Relative low Prevotella abundance in PD patients appears to be related to severe phenotypes of the disease; PIGD and mixed phenotypes. Severe constipation was more presented in PD cases which may be considered as a preclinical biomarker for PD.
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