Seid, A., Berhane, N., Abayneh, T., Tesfaye, S. (2022). Impacts of pathogen-host-drug interaction in the evolution and spread of antimicrobial-resistant pathogens. Microbes and Infectious Diseases, 3(2), 286-295. doi: 10.21608/mid.2021.105562.1209
aynias Seid; Nega Berhane; Takele Abayneh; Solomon Tesfaye. "Impacts of pathogen-host-drug interaction in the evolution and spread of antimicrobial-resistant pathogens". Microbes and Infectious Diseases, 3, 2, 2022, 286-295. doi: 10.21608/mid.2021.105562.1209
Seid, A., Berhane, N., Abayneh, T., Tesfaye, S. (2022). 'Impacts of pathogen-host-drug interaction in the evolution and spread of antimicrobial-resistant pathogens', Microbes and Infectious Diseases, 3(2), pp. 286-295. doi: 10.21608/mid.2021.105562.1209
Seid, A., Berhane, N., Abayneh, T., Tesfaye, S. Impacts of pathogen-host-drug interaction in the evolution and spread of antimicrobial-resistant pathogens. Microbes and Infectious Diseases, 2022; 3(2): 286-295. doi: 10.21608/mid.2021.105562.1209
Impacts of pathogen-host-drug interaction in the evolution and spread of antimicrobial-resistant pathogens
1Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Ethiopia.
2Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Ethiopia
3Department of Veterinary Bacteriology, National Veterinary Institute (NVI), Bishoftu, Ethiopia
4Department of Biology, Faculty of Natural and Computational Science, University of Gondar, Ethiopia
Abstract
Background: The single antibiotic drug monotherapies have been used by clinicians in medical treatments of various infectious diseases including tuberculosis (TB); however, World Health Organization accredited the rise of antimicrobial resistant bacterial pathogens, is a major global health crisis. As a result, a widely promising strategy known as antibiotic drug combination therapies have been designed to combat the evolution of drug-resistant pathogens, to enhance the current treatment efficacy by combining more than two antibiotic drugs, and for the efficient treatment of numerous infectious diseases including TB, HIV/AIDS, malaria. However, the disease-causing pathogens became resistant to multiple antibiotic drugs and can no longer be destroyed. One of the influencing factors of antibiotic drug combination treatment success failure is pathogen-host-antibiotic interaction which affect the combined drug outcomes and may influence evolution of multidrug-resistant strains. In such context, the main objective of this review paper was to assess the impacts of pathogen-host-antibiotic interaction in the evolution and spread of multi-drug resistant pathogens against drug-combination therapy. Understanding the potential mechanisms of drug-drug, host-antibiotic and host-pathogen interactions help to inform decisions as to set-up in clinical settings in order to limit the evolution and spread of multi- drug resistant bacterial strains. Most significantly, in the near future sustainable bacterial infection therapies for potential adaptive pathogens include synergy-based drug combination and host-directed therapies in drug combination could be exercised to tackle the multi-drug resistance crisis by enhancing the combined drug treatment efficacy and prevent bacteria adapting to combination treatments.
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