Potential chemical compounds can inhibit SARS CoV-2 replication and open the way for the production of anti-SARS CoV-2 therapy.

Document Type : Review Article

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Microbiology Department, Faculty of science, Tanta University, Tanta, Egypt.

Abstract

The genome of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) has an untranslated region (UTR) that enhances the replication and transcription of RNA, and subgenomic RNA (sgRNA) which encodes the 4 structural proteins that are essential for viral replication. The host cell of SARS CoV-2 expresses an important enzyme called TMPRSS2 protease that allows the virus to invade the cell. Peptide conjugated phosphorodiamidate morpholino oligomers (PPMOs) and Benzylesulfonyl-d-arginine- proline-4-amidinobenzylamide (BAPA) chemicals have inhibited the expression of the TMPRSS2 in the influenza host cell.  Peptide conjugated phosphorodiamidate morpholino oligomers also inhibited the UTR of the influenza genome, sgRNA of the porcine reproductive and respiratory syndrome virus (PRRSV), and other locations in other respiratory viruses. The combination of these chemicals can inhibit the UTR and sgRNA of SARS CoV-2 and prevent the expression of the TMPRSS2 in the SARS CoV-2 host cell to stop SARS CoV-2 replication, which may help the production of a drug against SARS CoV-2 virus.

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