The Relation Between Neonatal Vitamin D deficiency and Early Onset Sepsis in Term Infants

Document Type : Original Article


1 Department of Clinical and Chemical Pathology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt.

2 Department of Pediatrics, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt.

3 Department of Pediatrics, Fayoum general hospital, Al Fayoum, Egypt.


Background: Vitamin D had an important influence on the innate and adaptive immune system. 25-hydroxyvitamin D (25(OH)D) serum level is known to be the best predictor of vitamin D level.
Objective is to determine the relationship between neonatal 25(OH)D level in early-onset sepsis (EOS) and its severity in term infants.
Methods: This case-control study was performed on 50 septic neonates admitted to Fayoum University Hospitals' Neonatal Intensive Care Unit as a case group, and 50 healthy neonates as a control group. Each subject was subjected to a detailed history and meticulous general & systemic examinations. Laboratory assessment in form of complete blood count with differential counts, C-reactive protein (CRP), blood culture, and serum 25(OH)D level in infants and within 72 hours of life.
Results: 25(OH)D levels in cases (4.91 ng/ml) were significantly lowered than those in controls (13.0 ng/ml) (p < /p>


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